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The severity of each item is graded semiquantitatively. Relatively quiescent osteocyte thatcontains only afew profiles of rERand a few mitochondria (/W).Thecell virtuallyfills the lacunathat it occupies; the arrows indicate where cytoplasmicprocesses extend into canaliculi

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If reduced blood flow (longerhepatic “dwell” time) allows 10% greater extraction, the20% of the 0.8 extraction ratio xenobiotic normally emerg-ing will be reduced to 12%, an almost halving of the doseentering the general circulation.

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