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Forexample, is it possible to truly know all of the risks associated with a given treat-ment? Can a “free and voluntary” decision really be made in the face of often uni-versally poor prognoses with no treatment alternatives? Can patients with a terminalillness truly grasp the nuances of a phase I trial and distinguish its objectives fromthose of standard clinical management? All of these questions challenge disclosure,voluntariness, and capacity, respectively, and show that it is often not possible toachieve the “ideal” consent process. The location of pain incertain disease such as appendicitis may be in a different area from in the non-pregnantpatient

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