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Interleukin family membersincluding IL-1, IL-2, IL-5, IL-8, and IL-13 are essential to theresponse to epithelial cell injury in the respiratory system.Prostaglandins, especially PGE and leukotrienes, have beenfocused as intracellular signaling molecules in the respiratoryinjury. The braincan maximally extract oxygen from around 50% of the saturated hemoglobin molecules,beyond which delivery is dependent upon perfusion to avoid dysoxia. Fish, poultry or red meatprovide about 10 mg per 100 g of edible portion. Ef?cacy depended on the ?ow rate used(up to 10 L/min) and was little dependent oncatheter positioning

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Brain pathology of vCJDshows abundant PrPSc deposition, particularly multiplefibrillary PrP plaques surrounded by a halo of spongiformvacuoles (“florid” plaques) and other PrP plaques, andamorphous pericellular and perivascular PrP deposits,especially prominent in the cerebellar molecular layer; thepathognomonic plaques in vCJD are called fl orid becausethey have the appearance of a flower with a dense cen-ter and surrounding ring of vacuoles (refer to Figure 9.15;Budka, 2003).

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